Outcomes of Frail Patients While Waiting for Kidney Transplantation: Differences between Physical Frailty Phenotype and FRAIL Scale

Journal of Clinical Medicine

Leocadio Rodríguez-Mañas¹  Ernestina Junyent²  Marta Crespo²  Carla Burballa²  Anna Bach²  María José Pérez-Sáez²  Anna Buxeda²  Dolores Redondo-Pachón²  Anna Faura²  Julio Pascual²  Carlos E. Arias-Cabrales²  Ester Marco³ 

[1] Geriatrics Department, Hospital Universitario de Getafe, 28905 Madrid, Spain;Nephrology Department, Hospital del Mar, 08003 Barcelona, Spain;Physical Medicine & Rehabilitation Department, Parc de Salut Mar (Hospital del Mar-Hospital de L’ESPERANÇA), 08003 Barcelona, Spain;

关键词: frailty;    FRAIL;    kidney transplant waiting list;   

DOI  :  10.3390/jcm11030672

来源: DOAJ

【 摘 要 】

Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16.3 vs. 7.4%, p = 0.013). Robust patients had fewer hospital admissions during the 1st year after listing (20.8% if PFP = 0 vs. 43.4% if ≥1, and 27.1% if FRAIL = 0 vs. 48.9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0.45 [0.26–0.77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not.

【 授权许可】

Unknown