Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice

Antioxidants

Indranil Sinha¹  Jiangning Yang²  Shafaat Hussain³  Ewa Swiezewska⁴  Xiaowei Zheng⁵  Ismael Valladolid-Acebes⁵  Magnus Bentinger⁵  Michael Tekle⁵  Cheng Schwank-Xu⁵  Gustav Dallner⁵  Kerstin Brismar⁵ 

[1]Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, SE-17177 Stockholm, Sweden

[2]Department of Medicine, Division of Cardiology, Karolinska Institutet, SE-17177 Stockholm, Sweden

[3]Department of Molecular and Clinical Medicine, University of Gothenburg, SE-41345 Gothenburg, Sweden

[4]Institute of Biochemistry and Biophysics, Polish Academy of Sciences, PL-02-106 Warsaw, Poland

[5]Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17177 Stockholm, Sweden

关键词: coenzyme Q;    antioxidants;    tocotrienol;    diabetes;    oxidative stress;    diabetes complications;   

DOI  :  10.3390/antiox10071070

来源: DOAJ

【 摘 要 】

Hyperglycemia, hyperlipidemia, and adiposity are the main factors that cause inflammation in type 2 diabetes due to excessive ROS production, leading to late complications. To counteract the effects of increased free radical production, we searched for a compound with effective antioxidant properties that can induce coenzyme Q biosynthesis without affecting normal cellular functions. Tocotrienols are members of the vitamin E family, well-known as efficient antioxidants that are more effective than tocopherols. Deh-T3β is a modified form of the naturally occurring tocotrienol-β. The synthesis of this compound involves the sequential modification of geranylgeraniol. In this study, we investigated the effects of this compound in different experimental models of diabetes complications. Deh-T3β was found to possess multifaceted capacities. In addition to enhanced wound healing, deh-T3β improved kidney and liver functions, reduced liver steatosis, and improved heart recovery after ischemia and insulin sensitivity in adipose tissue in a mice model of type 2 diabetes. Deh-T3β exerts these positive effects in several organs of the diabetic mice without reducing the non-fasting blood glucose levels, suggesting that both its antioxidant properties and improvement in mitochondrial function are involved, which are central to reducing diabetes complications.

【 授权许可】

Unknown