Trypsinogen activation peptide induces HMGB1 release from rat pancreatic acinar cells

Open Medicine

Bai Liang¹  Liu Yao¹  Wei Wei¹  Tian Fei¹  Wang Guoliang²  Liu Yan²  Dui Danhua³ 

[1] China Department of Hepatobiliaropancreatic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi563003, China;Department of Hepatobiliaropancreatic Surgery, Guizhou Provincial People’s Hospital, Guiyang, 550002, China;Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Zunyi Medical, College, Zunyi563003, China;

关键词: Pancreatic acinar cell;    Trypsinogen activation peptide;    High mobility group box-1;    Ethyl pyruvate;    Rat;   

DOI  :  10.1515/med-2017-0043

来源: DOAJ

【 摘 要 】

The development of acute pancreatitis (AP) is associated with intracellular events in pancreatic cells, as well as with early and late inflammatory responses; however, their underlying mechanisms remain unclear. This study investigated trypsinogen activation peptide (TAP)-induced release of high mobility group box-l (HMGB1) from pancreatic acinar cells and how ethyl pyruvate (EP) affects this release.

【 授权许可】

Unknown