A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

eLife

Hyunsu Lee¹  Raul Ramos²  Ji Won Oh³  Tao Peng⁴  Jung Chul Kim⁵  Christian Fernando Guerrero-Juarez⁶  June-Hyug Choi⁷  Antoni R Rossi⁷  Nanda Maya Mali⁷  Ran Zhao⁷  Eve Kandyba⁷  Maksim V Plikus⁷  Kiarash Khosrotehrani⁷  Anukriti Dhar⁷  Krzysztof Kobielak⁷  John Foley⁷  Kim Pham⁷  Jonathan Le⁷  Julien M D Legrand⁸  Qing Nie⁸  Bogi Andersen⁸  Xiaoyang Wang⁸  Hye-Lim Lee⁸  Xiaojie Wang⁸  Zhengquan Yu⁸  Xiaoling Cao⁸  Jung Min Park⁸  Shelby C Jocoy⁸  Moonkyu Kim⁸  Brian Vu⁸  Qixuan Wang⁹  Melisa A Fuentes⁹ 

[1] Beijing Advanced Innovation Center for Food Nutrition and Human Health and State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China;Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea;Center for Complex Biological Systems, University of California, Irvine, United States;Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea;Department of Burn Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;Hair Transplantation Center, Kyungpook National University Hospital, Daegu, Korea;Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States;Department of Developmental and Cell Biology, University of California, Irvine, United States;Department of Mathematics, University of California, Irvine, United States;

关键词: hair follicle;    skin;    pattern formation;   

DOI  :  10.7554/eLife.22772

来源: DOAJ

【 摘 要 】

The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns. Ear skin behaves as a hyper-refractory domain with HFs in extended rest phase. Such hyper-refractivity relates to high levels of BMP ligands and WNT antagonists, in part expressed by ear-specific cartilage and muscle. Hair growth stops at the boundaries with hyper-refractory ears and anatomically discontinuous eyelids, generating wave-breaking effects. We posit that similar mechanisms for coupled regeneration with dominant activator, hyper-refractory, and wave-breaker regions can operate in other actively renewing organs.

【 授权许可】

Unknown