New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y2) isolated from the South China Sea

Beilstein Journal of Organic Chemistry

Lei He¹  Yongjun Lu¹  Zhaoming Liu²  Senhua Chen²  Zhigang She²  Yayue Liu² 

[1] Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou 510080, China;School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xin gang West Road, Guangzhou 510275, China;

关键词: endophytic fungus;    depsidone;    α-glucosidase inhibitory activity;    isoindolinone;    Meyerozyma guilliermondii;   

DOI  :  10.3762/bjoc.11.133

来源: DOAJ

【 摘 要 】

Three new depsidones, botryorhodines E–G (1–3), and two new isoindolinones, meyeroguillines A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry (HREIMS). Compounds 1–6 exhibited strong α-glucosidase inhibitory activity with IC50 values ranging from 2.1 to 13.3 μM. Moreover, kinetic studies of compounds 2 and 6 showed that both of them were noncompetitive inhibitors of α-glucosidase.

【 授权许可】

Unknown