Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma

Frontiers in Oncology

Miguel Cordova-Delgado¹  Mauricio P. Pinto²  Marcelo Garrido²  Gonzalo Pizarro²  Maria Elisa Herrera³ 

[1] Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile;Hematology and Oncology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, Chile;Medical Oncology Department, Clínica Alemana de Valdivia, Valdivia, Chile;Medical Oncology Department, Hospital de Valdivia, Valdivia, Chile;

关键词: case report;    small bowel adenocarcinoma;    comprehensive genomic profiling;    precision oncology;    therapeutic options;   

DOI  :  10.3389/fonc.2021.593561

来源: DOAJ

【 摘 要 】

Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingly, one of them had gene alterations that affected signaling pathways previously described for SBA. However, a second patient displayed previously unreported alterations in this particular tumor type. Based on these findings we discuss potential treatment options for patients affected by this rare, aggressive disease.

【 授权许可】

Unknown