Central modulation of cardiac baroreflex moment‐to‐moment sensitivity during treadmill exercise in conscious cats

Physiological Reports

Nan Liang¹  Mitsuhiro Idesako¹  Kanji Matsukawa¹  Ryota Asahara²  Kei Ishii² 

[1]Department of Integrative Physiology, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

[2]Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology Ibaraki Japan

关键词: baroreflex slope;    central command;    exercise intensity transition;    voluntary exercise;   

DOI  :  10.14814/phy2.15371

来源: DOAJ

【 摘 要 】

Abstract It remains undetermined whether the cardiac component of the entire arterial baroreflex is blunted even at the onset of low‐intensity exercise. We sought to examine the moment‐to‐moment sensitivity of the cardiac baroreflex during walking at different speeds and the presumed mechanisms responsible for baroreflex modulation in conscious cats. Arterial baroreflex sensitivity for heart rate was estimated from the baroreflex ratio between changes in systolic arterial blood pressure and heart rate and from the slope of the baroreflex curve between the cardiovascular responses to brief occlusion of the abdominal aorta. Treadmill walking was performed for 1 min at three levels of speed (low: 20–30 m/min, moderate: 40 m/min, and high: 50–60 m/min) or for 3 min at the stepwise change of speed (low to high to low transition). Cardiac baroreflex sensitivity was blunted at the onset of walking, irrespective of speed. Thereafter, the blunted cardiac baroreflex sensitivity was restored around 15 s of walking at any speed, while the blunting occurred again at 45 s of high‐speed walking. The inhibition of cardiac baroreflex sensitivity also occurred (1) during the speed transition from low to high and (2) at 45 s of high‐speed exercise of the stepwise exercise. The blunted cardiac baroreflex sensitivity was restored immediately to the resting level during the speed transition from high to low, despite sustained pressor and tachycardiac responses. Therefore, moment‐to‐moment modulation of the cardiac baroreflex during exercise would occur in association with motor intention (i.e., exercise onset) and effort (i.e., treadmill speed).

【 授权许可】

Unknown