Cerebellar Repetitive Transcranial Magnetic Stimulation and Noisy Galvanic Vestibular Stimulation Change Vestibulospinal Function

Frontiers in Neuroscience

Koichi Hosomi²  Nobuhiko Mori²  Youichi Saitoh²  Rikiya Hasada³  Shinya Douchi⁴  Akiyoshi Matsugi⁶  Satoru Nishishita⁸  Naoki Yoshida⁸  Yohei Okada⁹ 

[1] Department of Neuromodulation and Neurosurgery, Graduate School of Medicine, Osaka University, Osaka, Japan;Department of Neurosurgery, Graduate School of Medicine, Osaka University, Osaka, Japan;Department of Rehabilitation, Nagahara Hospital, Higasiosaka, Japan;Department of Rehabilitation, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;Faculty of Health Sciences, Kio University, Koryo, Japan;Faculty of Rehabilitation, Shijonawate Gakuen University, Daito, Japan;Institute of Rehabilitation Science, Tokuyukai Medical Corporation, Toyonaka, Japan;Kansai Rehabilitation Hospital, Toyonaka, Japan;Neurorehabilitation Research Center, Kio University, Koryo, Japan;

关键词: cerebellum;    transcranial magnetic stimulation;    H-reflex;    vestibular;    galvanic vestibular stimulation;   

DOI  :  10.3389/fnins.2020.00388

来源: DOAJ

【 摘 要 】

BackgroundThe cerebellum strongly contributes to vestibulospinal function, and the modulation of vestibulospinal function is important for rehabilitation. As transcranial magnetic stimulation (TMS) and electrical stimulation may induce functional changes in neural systems, we investigated whether cerebellar repetitive TMS (crTMS) and noisy galvanic vestibular stimulation (nGVS) could modulate vestibulospinal response excitability. We also sought to determine whether crTMS could influence the effect of nGVS.MethodsFifty-nine healthy adults were recruited; 28 were randomly allocated to a real-crTMS group and 31 to a sham-crTMS group. The crTMS was conducted using 900 pulses at 1 Hz, while the participants were in a static position. After the crTMS, each participant was allocated to either a real-nGVS group or sham-nGVS group, and nGVS was delivered (15 min., 1 mA; 0.1–640 Hz) while patients were in a static position. The H-reflex ratio (with/without bilateral bipolar square wave pulse GVS), which reflects vestibulospinal excitability, was measured at pre-crTMS, post-crTMS, and post-nGVS.ResultsWe found that crTMS alone and nGVS alone have no effect on H-reflex ratio but that the effect of nGVS was obtained after crTMS.ConclusioncrTMS and nGVS appear to act as neuromodulators of vestibulospinal function.

【 授权许可】

Unknown