HLA-A∗03:01 is associated with increased risk of fever, chills, and stronger side effects from Pfizer-BioNTech COVID-19 vaccination

HGG Advances

Iva Neveux¹  Joseph J. Grzymski¹  Simon White²  Nicole L. Washington²  Magnus Isaksson²  William Lee²  Kelly M. Schiabor Barrett²  Alexandre Bolze²  Elizabeth T. Cirulli²  Shaun Dabe³ 

[1] Center for Genomic Medicine, Desert Research Institute, 2215 Raggio Parkway, Reno, NV 89512, USA;Helix, 101 South Ellsworth Avenue, Suite 350, San Mateo, CA 94401, USA;Renown Health, 1155 Mill Street, Reno, NV 89502, USA;

关键词: COVID;    COVID-19;    vaccination;    HLA;    SARS-CoV-2;    HLA-A;   

DOI  :  

来源: DOAJ

【 摘 要 】

COVID-19 vaccines are safe and highly effective, but some individuals experience unpleasant reactions to vaccination. As the majority of adults in the United States have received a COVID-19 vaccine this year, there is an unprecedented opportunity to study the genetics of reactions to vaccination via surveys of individuals who are already part of genetic research studies. Here, we have queried 17,440 participants in the Helix DNA Discovery Project and Healthy Nevada Project about their reactions to COVID-19 vaccination. Our genome-wide association study identifies an association between severe difficulties with daily routine after vaccination and HLA-A∗03:01. This association was statistically significant only for those who received the Pfizer-BioNTech vaccine (BNT162b2; n = 3,694; p = 4.70E−11; OR = 2.07 [95% CI 1.67–2.56]), and showed a smaller effect size in those who received the Moderna vaccine (mRNA-1273; n = 3,610; p = 0.005; OR = 1.32 [95% CI 1.09–1.59]). In Pfizer-BioNTech recipients, HLA-A∗03:01 was associated with a 2-fold increase in risk of self-reported severe difficulties with daily routine following vaccination. The effect was consistent across ages, sexes, and whether the person had previously had a COVID-19 infection. The reactions experienced by HLA-A∗03:01 carriers were driven by associations with chills, fever, fatigue, and generally feeling unwell.

【 授权许可】

Unknown