Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function

Journal of Clinical Medicine

BoKyung Koo¹  Jihyeon Kim²  SeongA Shin³  Soowon Park⁴  MinKyong Moon⁵  Jun-Young Lee⁵  YuKyeong Kim⁶  DongHyun Yoon⁷  Jiyeon Lee⁸  Hongrae Kim⁸ 

[1] SMG-SNU Boramae Medical Center, Seoul 07061, Korea;College of Medicine, Seoul National University, Seoul 03080, Korea;Department of Biomedical Sciences, Seoul National University, Seoul 08826, Korea;Department of Education, Sejong University, Seoul 05006, Korea;;Department of Internal Medicine, Seoul National University College of Medicine &Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul 07061, Korea;Department of Psychiatry and Behavioral Science, SMG-SNU Boramae Medical Center, Seoul 07061, Korea;Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea;

关键词: Alzheimer’s disease;    Insulin Resistance;    Cognitive Decline;    Gray Matter;   

DOI  :  10.3390/jcm7110413

来源: DOAJ

【 摘 要 】

Background: It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline. Methods: We recruited 160 participants (78 with Alzheimer’s disease and 82 without Alzheimer’s disease). Insulin resistance, regional gray matter volume, and cognitive function were assessed. A hierarchical moderated multiple regression (MMR) model was used to determine any associations among insulin resistance, structural changes in the brain, and cognitive decline. Results: The volumes of 7 regions in the gray matter were negatively related to insulin resistance in Alzheimer’s disease (p =0.032). Hierarchical MMR analysis indicated that insulin resistance did not directly affect the cognitive decline but moderated the cognitive decline through the decrease in gray matter volume in the key brain regions, i.e., inferior orbitofrontal gyrus (left), middle cingulate gyrus (right), hippocampus (right), and precuneus (right) (p < 0.05 in each case). Conclusion: Insulin resistance appears to exacerbate the cognitive decline associated with several gray matter volume loss.

【 授权许可】

Unknown