New Cyclic Diarylheptanoids from Platycarya strobilacea

Molecules

You-zhi Li¹  Wen-bing Ding¹  Rui-yuan Zhao²  Bing-lei Liu²  Hua-liang He³  Guan-hua Li³  Jin Xue³  Lin Qiu³ 

[1] Hunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China;Hunnan Cotton Science Institute, Changde 415100, China;National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China;

关键词: cyclic diarylheptanoid;    Platycarya strobilacea;    Juglandaceae;    corticosterone-induced apoptosis;   

DOI  :  10.3390/molecules25246034

来源: DOAJ

【 摘 要 】

Five new cyclic diarylheptanoids (platycary A–E, compounds 1–5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1–5 and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds 1 and 2 significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ.

【 授权许可】

Unknown