Immune Checkpoint Inhibitor-Induced Diabetes Mellitus: Potential Role of T Cells in the Underlying Mechanism

International Journal of Molecular Sciences

NadimS. Azar¹  AssaadA. Eid¹  Diane Mourad²  SamiT. Azar² 

[1] Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut 11072020, Lebanon;Department of Internal Medicine, Endocrinology Division, Faculty of Medicine and Medical Center, American University of Beirut, Beirut 11072020, Lebanon;

关键词: immune checkpoint inhibitors;    immune-related adverse events;    autoimmune diabetes;    type I diabetes mellitus;    immune checkpoint inhibitor-induced diabetes mellitus;    PD-1;   

DOI  :  10.3390/ijms22042093

来源: DOAJ

【 摘 要 】

Immunotherapy is now a recognized treatment option for several types of cancer. However, some cancer patients treated with immune checkpoint inhibitors (ICIs) are subject to immune-related adverse events, including induced diabetes mellitus. The exact role and molecular/genetic action of ICIs in diabetes are still not well understood. Elucidating the underlying mechanisms in a proper fashion would allow better refining of biomarkers that would help diagnose patients at risk of altered immune system homeostasis, but would also hold the potential of new therapeutic options for diabetes. In the present narrative review, we propose to discuss the case of autoimmune diabetes following treatment with ICIs and the role of ICIs in the pathophysiology of diabetes. We also present some scarce available data on interesting potential immune therapies for diabetes.

【 授权许可】

Unknown