Protective effect of metformin on D-galactose-induced aging model in mice

Iranian Journal of Basic Medical Sciences

Amin khaluoi¹  Sara Heydari¹  Ayat Kaeidi²  Mohammad Allahtavakoli²  Iman Fatemi²  Ali Shamsizadeh² 

[1] Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

[2] Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;

关键词: Aging;    D-galactose;    Metformin;    Mouse;    Oxidative stress;   

DOI  :  10.22038/ijbms.2017.24331.6071

来源: DOAJ

【 摘 要 】

Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Results: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. Conclusion: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors.

【 授权许可】

Unknown