Metformin in metabolic syndrome treatment

Кардиоваскулярная терапия и профилактика

V. I. Makolkin¹  V. I. Podzolkov¹  D. A. Napalkov¹ 

[1]I.M. Sechenov Moscow Medical Academy, Moscow

关键词: metabolic syndrome;    treatment;    metformin;    calcium antagonists;    c-reactive protein;    carbohydrate and lipid metabolism;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aim. To compare the influence of standard and complex (including metformin) antihypertensive therapy on 24- hour blood pressure monitoring (BPM), biochemical and hormonal parameters in patients with metabolic syndrome (MS). Material and Methods. The study included 54 patients with MS: 34 males and 20 females aged 30-61, without manifested Type 2 diabetes mellitus (DM). Group A (28 MS patients) received antihypertensive drugs only – verapamil, if necessary combined with ACE inhibitors and diuretics. Group B (25 MS patients) was additionally administered metformin. At baseline and after 8-week therapy, 24-hour BPM was performed; basal levels of insulin, C-reactive protein (CRP), cholesterol, triglycerides (TG), high-density lipoproteins (HDL), and uric acid were measured. Results. In Group A, there was no significant dynamics in lipid and carbohydrate metabolism parameters. In Group B, basal levels of CRP (p<0.05), TG (p<0.1) had decreased, and HDL concentration has increased (p<0.01). Conclusion. In MS patients without DM, adding minimal therapeutic doses of metformin to standard antihypertensive treatment significantly improved lipid and carbohydrate metabolism parameters.

【 授权许可】

Unknown