Targeting Galectins With Glycomimetics

Frontiers in Chemistry

Sara Bertuzzi¹  Jon I. Quintana¹  Ana Ardá¹  Ana Gimeno¹  Jesús Jiménez-Barbero² 

[1] CIC bioGUNE, Basque Research Technology Alliance, Derio, Spain;Department of Organic Chemistry II, Faculty of Science and Technology, University of the Basque Country - UPV-EHU, Leioa, Spain;Ikerbasque, Basque Foundation for Science, Bilbao, Spain;

关键词: galectins;    glycomimetics;    glycans;    molecular recogntion;    drug design;   

DOI  :  10.3389/fchem.2020.00593

来源: DOAJ

【 摘 要 】

Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation. Their involvement in crucial pathologies makes them interesting targets for drug discovery. In this review, we gather the last approaches toward the specific design of glycomimetics as potential drugs against galectins. Different approaches, either using specific glycomimetic molecules decorated with key functional groups or employing multivalent presentations of lactose and N-acetyl lactosamine analogs, have provided promising results for binding and modulating different galectins. The review highlights the results obtained with these approximations, from the employment of S-glycosyl compounds to peptidomimetics and multivalent glycopolymers, mostly employed to recognize and/or detect hGal-1 and hGal-3.

【 授权许可】

Unknown