Renal detection of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in malaria associated acute kidney injury: a retrospective case–control study

BMC Research Notes

Atreyi Pramanik¹  Pragyan Acharya¹  Charandeep Kaur¹  Rajendra Mandage¹  Sanjay Kumar Agarwal²  Geetika Singh³  Amit Kumar Dinda³  Kalpana Kumari³  Arvind Bagga⁴  Jhuma Sankar⁴  Aditi Sinha⁴ 

[1] Department of Biochemistry, All India Institute of Medical Sciences;Department of Nephrology, All India Institute of Medical Sciences;Department of Pathology, All India Institute of Medical Sciences;Department of Pediatrics, All India Institute of Medical Sciences;

关键词: Acute kidney injury (AKI);    Plasmodium;    falciparum;    vivax;    knowlesi;    Complicated malaria;   

DOI  :  10.1186/s13104-020-4900-1

来源: DOAJ

【 摘 要 】

Abstract Objective Acute kidney injury (AKI) is a frequent presentation in malaria infections. Several cases of AKI that are accompanied by clinical symptoms of malaria infection, such as fever, nausea, respiratory distress, and anemia remain undiagnosed due to challenges in accurate diagnosis using peripheral blood microscopy and rapid diagnostic tests that are currently used in clinical settings. This is particularly true for P. vivax and P. knowlesi infections. As a result, these patients are not able to receive anti-malarial therapy in a timely manner. The objective of the present study was to investigate if patients presenting with AKI harbored any of the five human Plasmodium species (P. falciparum, P. vivax, P. knowlesi, P. malariae, and P. ovale) within their renal tissues. Results We found that renal biopsies from malaria associated AKI patients harbor the human malaria parasites P. falciparum, P. vivax and P. knowlesi as mono- and mixed species infections. Presence of microvascular injury in a majority of the malaria associated AKI cases suggested vascular involvement of P. vivax and P. knowlesi. This research note also highlights P. knowlesi as an emerging pathogen in the Indian subcontinent.

【 授权许可】

Unknown