Subcellular Localization of miRNAs and Implications in Cellular Homeostasis

Genes

Yuliang Feng¹  Moran Zhang²  Zhili Wen²  Wei Huang³  Hao Jiang⁴  Minwen Jie⁴  Tong Feng⁴ 

[1] Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, Headington, Oxford OX3 7LD, UK;Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China;Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;Laboratory for Aging and Cancer Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China;

关键词: microRNA;    subcellular localization;    transcriptional regulation;    phase separation;    condensate;   

DOI  :  10.3390/genes12060856

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization of miRNAs. Based on miRNA subcellular localization, unconventional functions and mechanisms at the transcriptional and post-transcriptional levels have been identified. This minireview provides an overview of the subcellular localization of miRNAs and the mechanisms by which they regulate transcription and cellular homeostasis in mammals, with a particular focus on the roles of phase-separated biomolecular condensates.

【 授权许可】

Unknown