Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults

Endocrinology and Metabolism

Cortni S. Couture¹  Keagan Dunville¹  Travis B. Conley²  Wayne W. Campbell²  Jung Eun Kim²  Ji Xin Cheng³  Junjie Li³ 

[1] Department of Chemistry, Purdue University College of Science, West Lafayette, IN, USA.;Department of Nutrition Science, Purdue University College of Health and Human Sciences, West Lafayette, IN, USA.;Weldon School of Biomedical Engineering, Purdue University College of Engineering, West Lafayette, IN, USA.;

关键词: Glucose homeostasis;    Intermuscular adipose tissue;    Intramyocellular lipid;    Overweight and obesity;    Middle-aged and older adults;   

DOI  :  10.3803/EnM.2017.32.2.257

来源: DOAJ

【 摘 要 】

BackgroundInsulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This study examined associations among IMAT content, IMCL saturation, and fasting glucose concentration in middle-aged and older adults with overweight or obesity.MethodsSeventy-five subjects (26 males, 49 females) were recruited and thigh muscle and IMAT were assessed using magnetic resonance imaging. Vastus lateralis tissue was acquired from a subset of nine subjects and IMCL content and saturation were assessed using nonlinear dual complex microscopy.ResultsThe characteristics of the 75 subjects were as follows: age 59±11 years, body mass index 30±5 kg/m2, fasting glucose concentration 5.2±0.5 mmol/L, fasting insulin concentration 12.2±7.3 µU/mL, fasting homeostatic model assessment of insulin resistance (HOMA-IR) 2.9±2.0 (mean±SD). IMAT to muscle tissue (MT) volume ratio was positively associated with the saturated fatty acid to unsaturated fatty acid ratio in IMCL. IMAT:MT was positively associated with fasting glucose concentration and HOMA-IR. IMCL saturation was positively associated with fasting glucose concentration while muscle cell area, IMCL area, and % IMCL in muscle cell were not associated with fasting glucose concentration.ConclusionThese results indicate that higher intermuscular fat content and IMCL saturation may impact fasting glucose concentration in middle-aged and older adults with overweight or obesity. The centralization of adipose tissue in the appendicular region of the body may promote insulin resistance.

【 授权许可】

Unknown