Manganese-enhanced MRI: biological applications in neuroscience

Frontiers in Neurology

Clement eHamani²  Beatriz eMonteiro Longo⁴  Luciene eCovolan⁴  Fernando Fernandes Paiva⁵  Jackeline Moraes Malheiros⁵ 

[1] Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health;Division of Neurosurgery, Toronto Western Hospital, University of Toronto;Research Imaging Centre, Centre for Addiction and Mental Health;Universidade Federal de São Paulo;Universidade de Sao Paulo;

关键词: Anatomy;    Epilepsy;    Manganese;    Nociception;    MRI;    tracing;   

DOI  :  10.3389/fneur.2015.00161

来源: DOAJ

【 摘 要 】

Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems. The administration of the paramagnetic divalent ion manganese (Mn2+) enhances MRI contrast in vivo. Due to similarities between Mn2+ and calcium (Ca2+), the premise of manganese-enhanced MRI (MEMRI) is that the former may enter neurons and other excitable cells through voltage gated Ca2+ channels. As such, MEMRI has been used to trace neuronal pathways, define morphological boundaries, and study connectivity in morphological and functional imaging studies. In this article, we provide a brief overview of MEMRI and discuss recently published data to illustrate the usefulness of this method, particularly in animal models.

【 授权许可】

Unknown