Molecules | |
Multicomponent Crystal of Metformin and Barbital: Design, Crystal Structure Analysis and Characterization | |
Lan Jiang1  Xiaoshu Guan2  Linhong Cai2  Xiangnan Hu2  Cong Li2  Li Zhang2  | |
[1] College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China;Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China; | |
关键词: multicomponent crystal; crystal design; supramolecular synthon; metformin; barbital; | |
DOI : 10.3390/molecules26144377 | |
来源: DOAJ |
【 摘 要 】
The formation of most multicomponent crystals relies on the interaction of hydrogen bonds between the components, so rational crystal design based on the expected hydrogen-bonded supramolecular synthons was employed to establish supramolecular compounds with desirable properties. This theory was put into practice for metformin to participate in more therapeutic fields to search for a fast and simple approach for the screening of candidate crystal co-formers. The prediction of intermolecular synthons facilitated the successful synthesis of a new multicomponent crystal of metformin (Met) and barbital (Bar) through an anion exchange reaction and cooling crystallization method. The single crystal X-ray diffraction analysis demonstrated the hydrogen bond-based ureide/ureide and guanidine/ureide synthons were responsible for the self-assembly of the primary structural motif and extended into infinite supramolecular heterocatemeric structures.
【 授权许可】
Unknown