Multicomponent Crystal of Metformin and Barbital: Design, Crystal Structure Analysis and Characterization

Molecules

Lan Jiang¹  Xiaoshu Guan²  Linhong Cai²  Xiangnan Hu²  Cong Li²  Li Zhang² 

[1] College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China;Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China;

关键词: multicomponent crystal;    crystal design;    supramolecular synthon;    metformin;    barbital;   

DOI  :  10.3390/molecules26144377

来源: DOAJ

【 摘 要 】

The formation of most multicomponent crystals relies on the interaction of hydrogen bonds between the components, so rational crystal design based on the expected hydrogen-bonded supramolecular synthons was employed to establish supramolecular compounds with desirable properties. This theory was put into practice for metformin to participate in more therapeutic fields to search for a fast and simple approach for the screening of candidate crystal co-formers. The prediction of intermolecular synthons facilitated the successful synthesis of a new multicomponent crystal of metformin (Met) and barbital (Bar) through an anion exchange reaction and cooling crystallization method. The single crystal X-ray diffraction analysis demonstrated the hydrogen bond-based ureide/ureide and guanidine/ureide synthons were responsible for the self-assembly of the primary structural motif and extended into infinite supramolecular heterocatemeric structures.

【 授权许可】

Unknown