Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions

Cells

Parveen Bazard¹  Alejandro A. Acosta¹  Dominika Borakiewicz¹  Mark A. Bauer¹  Mark Thivierge¹  Lauren R. Paganella¹  Bo Ding¹  Xiaoxia Zhu¹  Jennifer Pineros¹  Robert D. Frisina¹  Freyda L. Mannering² 

[1] Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA;Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA;

关键词: aging;    inflammaging;    auditory system;    age-related hearing loss;    cochlea;   

DOI  :  10.3390/cells10102761

来源: DOAJ

【 摘 要 】

The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age.

【 授权许可】

Unknown