Fabrication of Magnetic Molecularly Imprinted Beaded Fibers for Rosmarinic Acid

Nanomaterials

RashaMohamed El Nashar¹  IslamS. M. Khalil²  Boris Mizaikoff³  Mohamed Elwi⁴  Youssef Hamed⁵  Heba Handoussa⁶  EngyM. Saad⁷  NesrineAbdelrehim El Gohary⁷  BasmaM. El-Shenawy⁸  Anke Klingner⁹ 

[1] Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt;Department of Biomechanical Engineering, University of Twente, 7522 NB Enschede, The Netherlands;Institute of Analytical and Bioanalytical Chemistry, Ulm University, 89081 Ulm, Germany;Materials Engineering Department, Faculty of engineering and Materials Science, German University in Cairo, Cairo 11835, Egypt;Mechatronics Department, Faculty of engineering and Materials Science, German University in Cairo, Cairo 11835, Egypt;Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt;Pharmaceutical Chemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt;Pharmaceutical Technology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt;Physics Department, German University in Cairo, Cairo 11835, Egypt;

关键词: molecularly imprinted fibers;    electrospinning;    polycaprolactone;    design of experiments;    microrobots;    drug release;   

DOI  :  10.3390/nano10081478

来源: DOAJ

【 摘 要 】

The present study describes the fabrication of molecularly imprinted (MI) magnetic beaded fibers using electrospinning. Rosmarinic acid was selected as exemplary yet relevant template during molecular imprinting. A “design of experiments” methodology was used for optimizing the electrospinning process. Four factors, i.e., the concentration of the biodegradable polymer (polycaprolactone), the applied voltage, the flow rate, and the collector distance were varied in a central composite design. The production process was then optimized according to the suitability of the beaded fibers during microrobot fabrication, actuation, and drug release. The optimum average fiber diameter of MI beaded fibers was determined at 857 ± 390 nm with an average number of beads at 0.011 ± 0.002 per µm². In vitro release profiles of the optimized MI beaded fibers revealed a lower burst rate and a more sustained release when compared to control fibers. Magnetic control of the MI beaded fibers was successfully tested by following selected waypoints along a star-shaped predefined trajectory. This study innovatively combines molecular imprinting technology with magnetic microrobots enabling targeted drug delivery systems that offer precise motion control via the magnetic response of microrobots along with selective uptake of a drug into the microrobot using MI beaded fibers in future.

【 授权许可】

Unknown