Endomembrane remodeling and dynamics in Salmonella infection

Microbial Cell

Stéphane Méresse¹  Ziyan Fang¹ 

[1] Aix Marseille University, CNRS, INSERM, CIML, Marseille, France.;

关键词: salmonella;    molecular motors;    type 3 secretion system;    effectors;   

DOI  :  10.15698/mic2022.02.769

来源: DOAJ

【 摘 要 】

Salmonellae are bacteria that cause moderate to severe infections in humans, depending on the strain and the immune status of the infected host. These pathogens have the particularity of residing in the cells of the infected host. They are usually found in a vacuolar compartment that the bacteria shape with the help of effector proteins. Following invasion of a eukaryotic cell, the bacterial vacuole undergoes maturation characterized by changes in localization, composition and morphology. In particular, membrane tubules stretching over the microtubule cytoskeleton are formed from the bacterial vacuole. Although these tubules do not occur in all infected cells, they are functionally important and promote intracellular replication. This review focuses on the role and significance of membrane compartment remodeling observed in infected cells and the bacterial and host cell pathways involved.

【 授权许可】

Unknown