Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles

Pharmaceutics

Abdelbary Elhissi¹  Hina Zahid²  KanwalMuhammad Iqbal³  MuhammadRaza Shah³  Muhammad Kawish³  Tooba Jabri³ 

[1] College of Pharmacy, QU Health, and Office of VP for Research and Graduate Studies, Qatar University, 2713 Doha, Qatar;Faculty of Pharmaceutical Sciences Dow University of Health Sciences Karachi, Karachi 74200, Pakistan;International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan;

关键词: iron oxide nanoparticles;    surface functionalization;    biocompatibility;    ceftriaxone;    oral delivery;   

DOI  :  10.3390/pharmaceutics12060492

来源: DOAJ

【 摘 要 】

The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N'-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic nanoparticles (CFT-MIH-MNPs). Atomic force microscopy (AFM) and dynamic light scattering (DLS) showed that the developed CFT loaded MIH-MNPs are spherical, with a measured hydrodynamic size of 184.0 ± 2.7 nm and negative zeta potential values (–20.2 ± 0.4 mV). Fourier transformed infrared spectroscopic (FTIR) analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiency (EE) of 79.4% ±1.5%, and the drug was released gradually in vitro and showed prolonged in vitro stability using simulated gastrointestinal tract (GIT) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.4 ± 1.8 µg/mL in comparison with its control (2.0 ± 0.6 µg/mL). Overall, the developed CFT-MIH-MNPs formulation was promising for provision of high drug entrapment, gradual drug release and suitability for enhancing the oral delivery of CFT.

【 授权许可】

Unknown