Depth of Remission Following First-Line Treatment Is an Independent Prognostic Marker for Progression-Free Survival in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

Cancers

MariusE. Mayerhoefer¹  Barbara Kiesewetter²  Markus Raderer²  Werner Dolak³  Ingrid Simonitsch-Klupp⁴ 

[1] Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria;Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, A-1090 Vienna, Austria;Department of Medicine III, Clinical Division of Gastroenterology and Hepatology, Medical University of Vienna, A-1090 Vienna, Austria;Department of Pathology, Medical University of Vienna, A-1090 Vienna, Austria;

关键词: malt lymphoma;    gastric malt lymphoma;    indolent lymphoma;    extranodal lymphoma;    helicobacter pylori;    prognostic factors;    treatment;   

DOI  :  10.3390/cancers12020492

来源: DOAJ

【 摘 要 】

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma responding to upfront treatment has an excellent outcome and no further therapy is recommended, even in the presence of residual disease. However, no data exist on the influence of initial depth of remission on progression-free survival (PFS). Methods: We investigated a correlation between PFS and depth of response, categorizing them as complete remission (CR), partial remission (PR) and stable disease (SD) in 137 consecutive patients at the Medical University Vienna. Results: All patients with Helicobacter pylori (H. pylori)-positive, localized disease received H. pylori eradication (70%, 96/137), while the remaining patients were treated with various modalities. The response rate was 67% for the entire collective and 58% for eradication only, with corresponding CR-rates of 48% and 38%. At a median follow-up of 56.2 months, the estimated PFS for the entire cohort was 34.2 months (95% Confidence Interval 16.0−52.4). Responding patients (=CR/PR) had a significantly longer PFS compared to SD (68.3 vs. 17.3 months, p < 0.001). This was also applicable to the eradication only cohort (49.0 vs. 17.3 months, p < 0.001) and remained significant after correction for MALT-IPI. Furthermore, CR significantly prolonged PFS over PR (p = 0.007 entire cohort, p = 0.020 eradication). Conclusions: Remission status correlated significantly with PFS, suggesting depth of remission as prognostic marker for long-term relapse-free survival.

【 授权许可】

Unknown