Fungal Endophthalmitis: A Comprehensive Review

Journal of Fungi

Abid A. Haseeb¹  Abdelrahman M. Elhusseiny²  Ahmed B. Sallam²  Kinza T. Ahmad²  Mohammad Z. Siddiqui² 

[1] Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA;Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA;

关键词: fungal endophthalmitis;    exogenous endophthalmitis;    endogenous endophthalmitis;    Candida;    Aspergillus;    antifungals;   

DOI  :  10.3390/jof7110996

来源: DOAJ

【 摘 要 】

Endophthalmitis is a serious ophthalmologic condition involving purulent inflammation of the intraocular spaces. The underlying etiology of infectious endophthalmitis is typically bacterial or fungal. The mechanism of entry into the eye is either exogenous, involving seeding of an infectious source from outside the eye (e.g., trauma or surgical complications), or endogenous, involving transit of an infectious source to the eye via the bloodstream. The most common organism for fungal endophthalmitis is Candida albicans. The most common clinical manifestation of fungal endophthalmitis is vision loss, but other signs of inflammation and infection are frequently present. Fungal endophthalmitis is a clinical diagnosis, which can be supported by vitreous, aqueous, or blood cultures. Treatment involves systemic and intravitreal antifungal medications as well as possible pars plana vitrectomy. In this review, we examine these essential elements of understanding fungal endophthalmitis as a clinically relevant entity, which threatens patients’ vision.

【 授权许可】

Unknown