Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study

Environmental Health and Preventive Medicine

Yasuhiro Nagata¹  Takahiro Maeda²  Yuji Shimizu²  Shin-Ya Kawashiri²  Yuko Noguchi²  Yuko Nabeshima-Kimura³  Naomi Hayashida⁴ 

[1] Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences;Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences;Department of Radiation Health Management, Fukushima Medical University;Division of Promotion of Collaborative Research on Radiation and Environment Health Effects, Atomic Bomb Disease Institute, Nagasaki University;

关键词: Anti-thyroid peroxidase antibody;    Cross-sectional study;    Normal thyroid function;    Thyroid cysts;    Thyroid hormone;   

DOI  :  10.1186/s12199-020-00844-x

来源: DOAJ

【 摘 要 】

Abstract Background Anti-thyroid peroxidase antibody (TPO-Ab) has been shown to cause autoimmune thyroiditis by inducing a deleterious influence on thyroid hormone synthesis. Further, thyroglobulin, which has an important role in thyroid hormone synthesis, is reported to be high in the fluid from thyroid cysts. Therefore, TPO-Ab could be associated with the presence of thyroid cyst, partly by affecting the activity of thyroid hormone synthesis. Methods To investigate the association between TPO-Ab and thyroid cysts, we conducted a cross-sectional study of 1432 Japanese with normal thyroid function [i.e., normal range of free triiodothyronine (free T3) and free thyroxine (free T4)] between the ages of 40 and 74 years, who participated in an annual health check-up. Results In men, the statistical power did not reach a statistical significance value. Additionally, subjects with TPO-Ab showed lower odds ratios (ORs) of thyroid cysts than those without TPO-Ab. In women, subjects with TPO-Ab showed significantly lower ORs of thyroid cysts than those without TPO-Ab. The fully adjusted ORs were 0.68 (0.40, 1.18) for men and 0.40 (0.27, 0.60) for women. When evaluating the association between logarithmic values of TPO-Ab titer and thyroid cysts in both men and women, a notable inverse correlation was observed. The fully adjusted ORs were 0.68 (0.50, 0.92) for men and 0.68 (0.57, 0.81) for women. Conclusion TPO-Ab titer revealed to be inversely associated with thyroid cysts among Japanese with normal thyroid function. The presence of a thyroid cyst could indicate a lower risk of having TPO-Ab among the general population with normal thyroid function.

【 授权许可】

Unknown