B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns

Frontiers in Oncology

Elisângela de Paula Silveira-Lacerda¹  Andris Figueiroa Bakuzis²  Naida Cristina Borges³  Carla Martí Castelló³  Marina Pacheco Miguel⁴ 

[1] Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil;Instituto de Física, Universidade Federal de Goiás, Goiânia, Brazil;Programa de Pós-Graduação em Ciência Animal, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Brazil;Setor de Patologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil;

关键词: Ehrlich solid carcinoma;    tumor vascularization;    ultrasound;    breast cancer;    comparative medicine;    growth pattern;   

DOI  :  10.3389/fonc.2020.560413

来源: DOAJ

【 摘 要 】

Ehrlich solid carcinoma (ESC) is one of the tumor models used in cancer research. Although it is widely used, it has no ultrasonographic descriptions. In this study, serial B-mode and Doppler ultrasonographic examinations were performed for 23 days for ESCs inoculated into 18 Swiss albino mice. The growth patterns were analyzed, and on the basis of their growth curve, the tumors were classified into two groups: fast growth (FG) and slow growth (SG). Ultrasonographic characteristics of the tumor’s capsule, margins, echogenicity, echotexture, vascular index (VI), distribution of vascular flow, and Doppler indices such as the resistive index, pulsatility index, and peak systolic velocity (SV) were analyzed and compared between the two groups. A high VI and earlier blood flow were noted in the FG group (p<0.05). Additionally, SV was higher in the FG group than in the SG group (13.28 ± 0.38 cm/s vs. 8.43 ± 0.26 cm/s). In contrast, a change in echogenicity and flow distribution patterns were observed, especially in FG tumors. Therefore, ESC presented with few ultrasonographic differences between FG and SG tumors, especially vascularization during the initial stages of tumor growth.

【 授权许可】

Unknown