Low-Density Lipoprotein Cholesterol and the Risk of Rheumatoid Arthritis: A Prospective Study in a Chinese Cohort

Nutrients

Shouling Wu¹  Bing Lu²  Hannah VanEvery³  Xiang Gao³  Liufu Cui⁴  Wenhao Yang⁴  Jinmei Su⁵  Le Bao⁶  Nancy Olsen⁷ 

[1] Department of Cardiology, Kailuan General Hospital, Xinhua E Avenue, Tangshan 063007, China;Department of Medicine, Harvard Medical School, Shattuck Street, Boston, MA 02115, USA;Department of Nutritional Sciences, The Pennsylvania State University, Pollock Road, University Park, PA 16802, USA;Department of Rheumatology and Immunology, Kailuan General Hospital, Xinhua E Avenue, Tangshan 063007, China;Department of Rheumatology, Peking Union Medical College Hospital, Dongdan N Street, Beijing 100006, China;Department of Statistics, The Pennsylvania State University, Pollock Road, University Park, PA 16802, USA;Division of Rheumatology, Department of Medicine, Penn State Milton S. Hershey Medical Center, University Drive, Hershey, PA 17033, USA;

关键词: rheumatoid arthritis;    prospective;    cohort;    cholesterol;    epidemiology;   

DOI  :  10.3390/nu14061240

来源: DOAJ

【 摘 要 】

Objective: This study aimed to investigate whether low-density lipoprotein cholesterol (LDL-C) concentration was associated with the risk of rheumatoid arthritis (RA) in Chinese adults. Methods: The study included the 97,411 participants in the Kailuan Study without RA, with complete baseline LDL-C data, and who did not use lipid-lowering medications at baseline or during follow-up. We used Cox proportional hazards modeling to calculate the hazard ratio (HR) and 95% confidence interval (95% CI) of RA according to baseline LDL-C tertiles, adjusting for age, sex, body mass index, HDL-C, triglycerides, diabetes, hypertension, alcohol consumption, and smoking. We also calculated the HR and 95% CI of RA using updated LDL-C measurements prior to the end of follow-up, adjusting for covariates. Results: We identified 97 incident RA cases between 2006 and 2018. After adjusting for potential confounders, updated LDL-C concentration—rather than baseline LDL-C—was inversely associated with RA risk. The adjusted HR of RA was 0.64 (95% CI: 0.38, 1.09; p-trend = 0.10) comparing the two extreme baseline LDL-C tertiles, and 0.38 (95% CI: 0.22, 0.64; p-trend < 0.01) comparing the two extreme tertiles of the updated LDL-C concentrations. Conclusions: In this prospective study, high LDL-C concentrations, when measured closest to RA diagnosis or the end of follow-up, were associated with a low risk of RA. These findings highlight the changes in LDL-C prior to RA diagnosis, and the importance of including lipid analyses into studies of the pathogenesis of RA.

【 授权许可】

Unknown