In Situ Photopolymerization of Acrylamide Hydrogel to Coat Cellulose Acetate Nanofibers for Drug Delivery System

Polymers

Khouloud Jlassi¹  Megan Pitz²  Angela Alexander-Bryant²  Md Arifuzzaman³  Daniel C. Whitehead³  Mohamed F. Attia³  Stephen S. Kelly⁴  Frank Alexis⁵  Ahmed S. Montaser⁶ 

[1] Center for Advanced Materials, Qatar University, Doha P.O. Box 2713, Qatar;Department of Bioengineering, Clemson University, Clemson, SC 29634, USA;Department of Chemistry, Clemson University, Clemson, SC 29634, USA;Department of Forest Biomaterials, College of Natural Resources, North Carolina State University, Raleigh, NC 27607, USA;School of Biological Sciences and Engineering, Yachay Tech University, Urcuqui 100650, Ecuador;Textile Research Division, Pretreatment and Finishing Department, National Research Center, Dokki, Cairo 12622, Egypt;

关键词: electrospinning;    cellulose acetate;    nanofibers;    poly(acrylamide) hydrogel;    drug delivery;    kinetic release;   

DOI  :  10.3390/polym13111863

来源: DOAJ

【 摘 要 】

In this study we developed electrospun cellulose acetate nanofibers (CANFs) that were loaded with a model non-steroidal anti-inflammatory drug (NSAID) (ibuprofen, Ib) and coated with poly(acrylamide) (poly-AAm) hydrogel polymer using two consecutive steps: an electrospinning process followed by photopolymerization of AAm. Coated and non-coated CANF formulations were characterized by several microscopic and spectroscopic techniques to evaluate their physicochemical properties. An analysis of the kinetic release profile of Ib showed noticeable differences due to the presence or absence of the poly-AAm hydrogel polymer. Poly-AAm coating facilitated a constant release rate of drug as opposed to a more conventional burst release. The non-coated CANFs showed low cumulative drug release concentrations (ca. 35 and 83% at 5 and 10% loading, respectively). Conversely, poly-AAm coated CANFs were found to promote the release of drug (ca. 84 and 99.8% at 5 and 10% loading, respectively). Finally, the CANFs were found to be superbly cytocompatible.

【 授权许可】

Unknown