The THINC-it Tool for Cognitive Assessment and Measurement in Major Depressive Disorder: Sensitivity to Change

Frontiers in Psychiatry

Christopher R. Bowie²  Rodrigo B. Mansur⁴  Tanya Tran⁵  Caroline Park⁶  Roger S. McIntyre⁶  Yena Lee⁶  Dominika Fus⁷  Flora Nasri⁷  Mehala Subramaniapillai⁷  Michelle Iacobucci⁷  Hannah Zuckerman⁷  Joshua D. Rosenblat⁷  Bing Cao⁷ 

[1] Brain and Cognition Discovery Foundation, Toronto, ON, Canada;Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada;Department of Pharmacology, University of Toronto, Toronto, ON, Canada;Department of Psychiatry, University of Toronto, Toronto, ON, Canada;Department of Psychology, Queen's University, Kingston, ON, Canada;Institute of Medical Science, University of Toronto, Toronto, ON, Canada;Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada;

关键词: major depressive disorder;    THINC-it tool;    validation;    screening;    measurement;    sensitivity;   

DOI  :  10.3389/fpsyt.2020.00546

来源: DOAJ

【 摘 要 】

BackgroundHerein, we sought to determine the sensitivity to change in cognitive function, as measured by the THINC-it tool, in a sample of adults with major depressive disorder (MDD) receiving standardized antidepressant therapy.MethodsAdults meeting the DSM-5 criteria for MDD with at least moderate depressive symptom severity [i.e., Montgomery Åsberg Depression Rating Scale (MADRS) total score ≥ 20] were treated with open-label vortioxetine (10–20 mg/day, flexibly-dosed) for 8 weeks. The previously validated THINC-it tool was the primary dependent measure. The THINC-it tool was validated against the paper and pencil version of the Digit Symbol Substitution Test (DSST) and the Trails Making Test B (TMTB).ResultsAfter 8 weeks of treatment, adults with MDD exhibited improvement in cognitive function relative to healthy controls (e.g., processing speed) (p = 0.031). A subdomain measure of working memory (i.e., symbol check; SC) exhibited significant improvement at Weeks 2 and 8 in latency (p = 0.032), SC accuracy (p = 0.046), and objective z-score (p = 0.001) independent of depressive symptoms. A linear regression analysis determined that the THINC-it tool measures of processing speed, as well as executive function were significantly associated with changes observed on the pencil and paper version the Digit Symbol Substitution Test (DSST) (p = 0.002) and in Trails Making Test B (TMTB) (p = 0.003), respectively.ConclusionThe THINC-it tool demonstrates sensitivity to change in adults with MDD and is highly correlated with improvements on pencil and paper versions of DSST and TMTB.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03053362.

【 授权许可】

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