Coincidence of Malignancy and Congenital Thrombophilia as the Cause of Deep Venous Thrombosis - Case Report and Review of the Literature

Acta Medica Martiniana

Z. Jedlnakova¹  I. Plamenova¹  M. Fedor¹  P. Kublsz¹  L. Lisa¹  J. Sokol¹  J. Stasko¹  L. Stanclakova¹ 

[1] National Centre of Haemostasis and Thrombosis, Clinic of Haematology and Transfusiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava and University Hospital in Martin, Slovak Republic;

关键词: deep venous thrombosis;    venous thromboembolism;    factor v leiden;    acute myeloid leukaemia;   

DOI  :  10.2478/acm-2014-0008

来源: DOAJ

【 摘 要 】

Introduction: Deep venous thrombosis (DVT, phlebothrombosis) is a very important clinical problem with its resultant fatal pulmonary embolism (PE) as one of the possible consequences. Factor V Leiden (FV Leiden) is a genetic disorder characterized by a poor anticoagulant response to activated protein C (APC) and an increased risk of venous thromboembolism (VTE). Homozygous carriers of the FV Leiden mutation are estimated to have an 80-fold increased lifetime relative risk of VTE. Most homozygous carriers present with VTE before 40 years of age, but some can live thrombosis-free until the sixth or seventh decade of life or even remain asymptomatic for life. Case-controlled studies of patients with cancer revealed a four-fold increase in thromboembolic occurrence in acute leukaemia, with the risk of thrombosis persisting even after remission of the disease.

【 授权许可】

Unknown