Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy

Pharmaceutics

Rita Muzzalupo¹  Lorena Tavano¹  Elisabetta Mazzotta¹ 

[1] Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Savinio, Ed. Polifunzionale, 87036 Arcavacata di Rende, Italy;

关键词: thermo-sensitivity;    hyperthermia;    liposomes;    vesicles;    drug delivery;    cancer;   

DOI  :  10.3390/pharmaceutics10030150

来源: DOAJ

【 摘 要 】

Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored.

【 授权许可】

Unknown