Methanolic extract of black garlic ameliorates diet-induced obesity via regulating adipogenesis, adipokine biosynthesis, and lipolysis

Journal of Functional Foods

Yi-Chen Chen¹  Tsai-Hua Kao²  Chin-Yin Tseng³  Chin-Lin Hsu⁴  Wei-Tang Chang⁴ 

[1] Department of Animal Science and Technology, National Taiwan University, Taipei City 106, Taiwan;Department of Food Science, Fu Jen University, Taipei 242, Taiwan;Department of Health Food, Chung Chou University of Science and Technology, Changhua County 510, Taiwan;School of Nutrition, Chung Shan Medical University, Taichung City 402, Taiwan;

关键词: Adipose tissue;    Black garlic extract;    High-fat diet;    Lipid metabolism;    Liver;   

DOI  :  

来源: DOAJ

【 摘 要 】

The objective of this study was to determine if methanolic extract of black garlic (MEBG) has antiobesity effects via regulating lipid metabolism in an animal model. The results indicate that supplementation with MEBG decreased the final body weight; the relative masses of the liver and fat tissues; serum triacylglyceride levels; and hepatic oxidative stress and increased faecal lipid contents in HFD rats. Supplementation with MEBG upregulated AMPK, FOXO1, Sirt1, ATGL, HSL, perilipin, ACO, CPT-1, and UCP1 in the adipose tissues of HFD rats, whereas it downregulated CD36. Meanwhile, MEBG upregulated adiponectin and downregulated PAI-1, resistin, TNF-α, and GLUT4 in the adipose tissues of HFD rats. Regarding hepatic gene expression, MEBG upregulated AMPK, Sirt1, and PPARα but downregulated SREBP-1c, ACC, FAS, and SCD1. Therefore, MEBG can be developed as a potential nutraceutical ingredient for the prevention of obesity in a niche market.

【 授权许可】

Unknown