Gonadotropin-Resistant Ovary Syndrome Presented with Secondary Amenorrhea and Infertility: A Case Report

Iranian Journal of Medical Sciences

Jamshid Rahmati¹  Ali Karimian²  Sara Davoodi³  Leila Ghasmpour³  Shaghayegh Moradi Alamdarloo³  Alamtaj Samsami³ 

[1] Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: primary ovarian insufficiency;    ovarian reserve;    infertility;    amenorrhea;   

DOI  :  10.30476/ijms.2019.81965.

来源: DOAJ

【 摘 要 】

Resistant ovary syndrome (ROS) is a presentation of hypergonadotrophic hypogonadism condition with very low incidence. Infertility is one of the most common complaints of women with this syndrome. We herein present a case of a 27-year-old woman with all features of secondary amenorrhea and secondary sexual characteristics. In 2018, the patient was referred to the Hazret-e-Zeinab Infertility Center affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. She was diagnosed with secondary amenorrhea and increased gonadotropin secretion after menopause. However, the patient had a normal antral follicle count, anti-Müllerian hormone level, 46, XX karyotype, and thyroid function. After taking oral contraceptives her menstruation started, but she showed no response to high doses of exogenous gonadotropins. She was advised to have an embryo derived from in vitro maturation. By using patients’ own oocyte maturation, this technique could be a better treatment for infertile women with ROS. This case report is particularly interesting due to the rarity of its prevalence and similarity with primary ovarian insufficiency.

【 授权许可】

Unknown