PAIRED ASSOCIATIVE STIMULATION WITH HIGH-FREQUENCY PERIPHERAL COMPONENT LEADS TO ENHANCEMENT OF CORTICOSPINAL TRANSMISSION AT WIDE RANGE OF INTERSTIMULUS INTERVALS

Frontiers in Human Neuroscience

Jyrki P Mäkelä¹  Pantelis Lioumis¹  Aleksandra Zubareva¹  Anastasia Shulga¹ 

[1] Helsinki University Hospital;

关键词: Spinal Cord;    Transcranial Magnetic Stimulation;    plasticity;    Paired associative stimulation;    Peripheral electrical stimulation;   

DOI  :  10.3389/fnhum.2016.00470

来源: DOAJ

【 摘 要 】

BackgroundIn spinal paired associative stimulation (PAS), orthodromic and antidromic volleys elicited by transcranial magnetic stimulation (TMS) and peripheral nerve stimulation (PNS) coincide at corticomotoneuronal synapses at the spinal cord. The interstimulus interval (ISI) between TMS and PNS determines whether PAS leads to motor-evoked potential (MEP) potentiation or depression. PAS applied as a long-term treatment for neurological patients might alter conduction of neural fibers over time. Moreover, measurements of motoneuron conductance for determination of ISIs may be challenging in these patients.ResultsWe sought to design a PAS protocol to induce MEP potentiation at wide range of ISIs. We tested PAS consisting of high-intensity (100% SO) TMS and high-frequency (50 Hz) PNS in 5 subjects at 5 different ISIs. Our protocol induced potentiation of MEP amplitudes in all subjects at all tested intervals. TMS and PNS alone did not result in MEP potentiation. The variant of PAS protocol described here does not require exact adjustment of ISIs in order to achieve effective potentiation of MEPs. ConclusionsThis variant of PAS might be feasible as a long-term treatment in rehabilitation of neurological patients.

【 授权许可】

Unknown