期刊论文详细信息
International Journal of Molecular Sciences
LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms
AlexeyA. Dmitriev1  ElenaA. Filippova2  AlexeyA. Moscovtsev2  EleonoraA. Braga2  NikolayE. Kushlinskii3  MarinaV. Fridman4 
[1] Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia;Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia;N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia;Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia;
关键词: ovarian cancer;    long non-coding RNAs;    competitive endogenous RNAs;    miRNAs;    oncogenic and suppressive lncRNAs;    metastasis;   
DOI  :  10.3390/ijms21228855
来源: DOAJ
【 摘 要 】

Ovarian cancer (OvCa) develops asymptomatically until it reaches the advanced stages with metastasis, chemoresistance, and poor prognosis. Our review focuses on the analysis of regulatory long non-coding RNAs (lncRNAs) competing with protein-coding mRNAs for binding to miRNAs according to the model of competitive endogenous RNA (ceRNA) in OvCa. Analysis of publications showed that most lncRNAs acting as ceRNAs participate in OvCa progression: migration, invasion, epithelial-mesenchymal transition (EMT), and metastasis. More than 30 lncRNAs turned out to be predictors of survival and/or response to therapy in patients with OvCa. For a number of oncogenic (CCAT1, HOTAIR, NEAT1, and TUG1 among others) and some suppressive lncRNAs, several lncRNA/miRNA/mRNA axes were identified, which revealed various functions for each of them. Our review also considers examples of alternative mechanisms of actions for lncRNAs besides being ceRNAs, including binding directly to mRNA or protein, and some of them (DANCR, GAS5, MALAT1, and UCA1 among others) act by both mechanisms depending on the target protein. A systematic analysis based on the data from literature and Panther or KEGG (Kyoto Encyclopedia of Genes and Genomes) databases showed that a significant part of lncRNAs affects the key pathways involved in OvCa metastasis, EMT, and chemoresistance.

【 授权许可】

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