Small-bowel mucosal changes in Egyptian cirrhotic patients with portal hypertension using capsule endoscopy versus single-balloon enteroscopy

Egyptian Liver Journal

Ali H. El-Dahrouty¹  Hesham K. H. Keryakos¹  Ibrahim Mostafa¹  Amr M. El-Sayed²  Nancy N. Fanous²  Zienab M. Saad² 

[1]Faculty of Medicine, Minia University

[2]Department of Tropical Medicine

关键词: Cirrhosis;    Portal hypertension;    Small bowel;    Capsule endoscopy;    Balloon enteroscopy;   

DOI  :  10.1186/s43066-020-00025-z

来源: DOAJ

【 摘 要 】

Abstract Background Small-bowel mucosal abnormalities that may occur secondary to portal hypertension in patients with liver cirrhosis have an impact on health and quality of life. In spite of the importance of these changes, little is known about the frequency and features of small-bowel changes in cirrhotic patients with portal hypertension. Eighty cirrhotic patients with or without esophageal or gastric varices were recruited in this study as well as 60 age- and sex-matched controls. All study participants underwent capsule endoscopy. In addition, half of the patients and controls were randomized to receive single-balloon enteroscopy. Results The prevalence of small-bowel mucosal changes was statistically significantly higher in cirrhotic patients than in controls; 57% versus 6.7%, respectively (p < 0.05). Cirrhotic patients with portal hypertensive gastropathy showed a significant increase in the small-bowel changes (p < 0.001). Small-bowel changes were significantly higher in patients with higher MELD and Child-Pugh scores (p < 0.001). Moreover, capsule endoscopy was more effective in the detection of small-bowel changes than single-balloon enteroscopy. Conclusions Mucosal changes associated with portal hypertensive enteropathy are more prevalent in cirrhotic patients, regardless of the presence or absence of gastric varices. Small-bowel mucosal changes in patients with portal hypertensive enteropathy were more common in patients who suffered from portal hypertensive gastropathy and were positively correlated with advanced chronic liver disease.

【 授权许可】

Unknown