Determining factors of functioning in hemodialysis patients using the international classification of functioning, disability and health

BMC Nephrology

Jaqueline de Paula C Freitas¹  Pedro Henrique S. Figueiredo¹  Henrique S. Costa¹  Ana Cristina R. Lacerda¹  Patrícia C. Campos¹  Ana C. R. Silva¹  Vanessa P. Lima¹  Jousielle Márcia Santos¹  Fidelis Antônio da Silva Junior¹  Vanessa A. Mendonça¹  Luciana M. M. Santos¹  Gabriele T. Gonçalves¹  Borja Sañudo²  Redha Taiar³  Mario Bernardo-Filho⁴  Vanessa G. B. Rodrigues⁵  Frederico L. Alves⁵  Maria Cecília S. M. Prates⁵  Emílio Henrique B. Maciel⁵ 

[1] Centro Integrado de Pós-Graduação e Pesquisa em Saúde (CIPq-Saúde), Universidade Federal dos Vales do Jequitinhonha e Mucuri;Department of Physical Education and Sports, Universidad de Sevilla;MATériaux et Ingénierie Mécanique (MATIM), Université de Reims Champagne-Ardenne;Mechanical Vibration Laboratory and Integrative Practices (LAVIMPI), Biophysics and Biometrics Department, Institute of Biology Roberto Alcântara Gomes and Piquet Carneiro Polyclinic, Universidade do Estado do Rio de Janeiro;Universidade Federal dos Vales do Jequitinhonha e Mucuri;

关键词: Hemodialysis;    Biomarker;    Body composition;    Parathormone;    Alkaline phosphatase;    Physical activity level;   

DOI  :  10.1186/s12882-022-02719-5

来源: DOAJ

【 摘 要 】

Abstract Background Hemodialysis (HD) treatment affects functioning, physical activity level, clinical biomarkers, and body composition. However, the association between these variables with functioning, considering International Classification of Functioning, Disability and Health (ICF) domains remains unclear. Thus, the aim of this study was to investigate the possible association between physical activity, biomarkers, and body composition with functioning in HD patients in reference to the ICF. Methods Eighty HD patients performed different tests grouped according to ICF domain: Body structure and function – handgrip strength (HS), 5-repetition sit-to-stand test, and 60-s sit-to-stand test (5-STS, 60-STS, respectively); Activity – short physical performance battery (SPPB); and Participation – participation scale questionnaire. Physical activity [Human Activity Profile questionnaire (HAP)], body composition (Dual-energy X-ray absorptiometry), Parathormone (PTH), and alkaline phosphatase were analyzed as possible variables associated with ICF domains. Data analyses were performed using simple and multiple regression models adjusted for age, duration of HD, and diuresis volume. Results In the body structure and function domain, appendicular lean mass, PTH level, and age were associated with HS (R2 = 0.558); HAP and PTH were associated with 5-STS (R2 = 0.263); and HAP, PTH, duration of HD, and age were associated with 60-STS (R2 = 0.337). In the activity domain, HAP, PTH, alkaline phosphatase, duration of HD, age, and body fat were associated with SPPB (R2 = 0.689). Finally, only HAP was associated with the participation scale (R2 = 0.067). Conclusion Physical activity and PTH levels are determinant protagonists of functioning in all ICF domains in hemodialysis patients.

【 授权许可】

Unknown