NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation

International Journal of Molecular Sciences

Gisa Tiegs¹  Katrin Neumann¹  Birgit Schiller¹ 

[1] Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;

关键词: sterile liver inflammation;    NLRP3 inflammasome;    IL-1β;    IL-33;    ILC2;    tregs;   

DOI  :  10.3390/ijms19092732

来源: DOAJ

【 摘 要 】

In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or “alarmin”, which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease.

【 授权许可】

Unknown