The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

Biomolecules

Zhenying Cai¹  Hyeyoun Chang¹  ThomasM. Roberts¹ 

[1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;

关键词: pi3k;    pten;    cancer;   

DOI  :  10.3390/biom9110713

来源: DOAJ

【 摘 要 】

In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors.

【 授权许可】

Unknown