Physiological Regulation of Innate Lymphoid Cells

Frontiers in Immunology

Cyril Seillet¹  Nicolas Jacquelot¹  Kylie Luong² 

[1] Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia;Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia;

关键词: innate lymphoid cells;    immunity;    homeostasis;    neuroendocrine regulation;    metabolites;    hormones;   

DOI  :  10.3389/fimmu.2019.00405

来源: DOAJ

【 摘 要 】

Discovery of innate lymphoid cells (ILCs) have provoked a paradigm shift in our understanding of the immune protection. Their constitutive presence and activity at the body's barrier surfaces ensure the maintenance of the tissue homeostasis and immune protection. This complex family has distinct and non-redundant functions that can have both beneficial and detrimental effects on disease outcome. The capacity of ILCs to perform their function effectively relies on their ability to sense and integrate intrinsic and extrinsic signals. Recent studies have shown that ILCs are not only sensitive to pathogen-derived stimuli but are also very well equipped to sense host-derived signals such as neuropeptides, hormones, and metabolites. The integration of these signals represents a complex and constant cross-talk between the immune system and the physiological systems of the body, including the nervous, endocrine, digestive, and reproductive systems. The physiological regulation of ILCs constitutes an important step in our understanding of the events leading to the protective and pathological properties of these cells. This review summarizes the recent advances in the understanding of the regulation of ILCs by physiological signals and their consequences on the maintenance of tissue homeostasis.

【 授权许可】

Unknown