Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

Cells

Marina Cindric¹  Lidija Milkovic²  Neven Zarkovic²  Ana Cipak Gasparovic²  Pierre-Alexis Mouthuy³ 

[1] Laboratory for Molecular Pathology, Department of Pathology and Cytology, University Hospital Centre Zagreb, Salata 10, 10000 Zagreb, Croatia;Laboratory for Oxidative Stress, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia;National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit, Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK;

关键词: reactive oxygen species (ROS);    redox signaling;    cellular processes;    physiology;    cancer;    metabolism;    therapy;   

DOI  :  10.3390/cells8080793

来源: DOAJ

【 摘 要 】

The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products of detrimental oxidative stress, they have been upgraded since, and now ROS are also known to be essential for the regulation of physiological cellular functions through redox signaling. In the majority of cases, metabolic demands, along with other stimuli, are vital for ROS formation and their actions. In this review, we focus on the role of ROS in regulating cell functioning and communication among themselves. The relevance of ROS in therapy concepts is also addressed here.

【 授权许可】

Unknown