Effects of Periodic Fasting on Fatty Liver Index—A Prospective Observational Study

Nutrients

Francoise Wilhelmi de Toledo¹  Stefan Drinda¹  Franziska Grundler¹  Nico Steckhan²  Andreas Michalsen³  Thomas Neumann⁴  Thomas Lehmann⁵ 

[1] Buchinger Wilhelmi Clinic, 88662 Überlingen, Germany;Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt–Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany;Department of Internal and Complementary Medicine, Immanuel Hospital Berlin, 14109 Berlin, Germany;Division of Rheumatology, Immunology and Rehabilitation, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland;Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, 07743 Jena, Germany;

关键词: periodic fasting;    obesity;    overweight;    fatty liver index;    diabetes;   

DOI  :  10.3390/nu11112601

来源: DOAJ

【 摘 要 】

This prospective observational trial investigated effects and safety of periodic fasting in subjects with and without type 2 diabetes mellitus (T2DM). The primary end point was set as the change of fatty liver index (FLI) as a surrogate parameter of non-alcoholic fatty liver disease (NAFLD). Six-hundred and ninety-seven subjects (38 with T2DM) were enrolled. A baseline FLI ≥ 60 (the threshold for fatty liver) was found in 264 subjects (37.9%). The mean duration of fasting was 8.5 ± 4.0 days (range 6–38). FLI decreased significantly (−14.02 ± 11.67; p < 0.0001), with a larger effect in individuals with T2DM (−19.15 ± 11.0; p < 0.0001; p = 0.002 compared to non-diabetic subjects). Body mass index (BMI) decreased by −1.51 ± 0.82 kg/m², and 49.9% of the subjects lost ≥5% body weight. After fasting, nearly half of the 264 subjects with FLI ≥ 60 (highest risk category) shifted to a lower category. The improvement of FLI correlated with the number of fasting days (r = −0.20, p < 0.0001) and with the magnitude of BMI reduction (r = 0.14, p = 0.0001). Periodic fasting with concomitant weight reduction leads to significant rapid improvement of FLI in subjects with and without T2DM.

【 授权许可】

Unknown