The Association of PPARγ Pro12Ala and C161T Polymorphisms with Polycystic Ovary Syndrome and Their Influence on Lipid and Lipoprotein Profiles

International Journal of Fertility and Sterility

Foroogh Chamaie-Nejad¹  Ziba Rahimi¹  Shohreh Saeidi¹  Asad Vaisi-Raygani²  Zohreh Rahimi³  Ali Ebrahimi³ 

[1] Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran;Department of Dermatology, Kermanshah University of Medical Sciences, Kermanshah, Iran;Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;

关键词: estradiol;    lipid;    lipoprotein;    peroxisome proliferator;    activated receptor;    polycystic ovary syndrome;   

DOI  :  10.22074/ijfs.2018.5270

来源: DOAJ

【 摘 要 】

BackgroundThe aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR)γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influenceon lipid and lipoprotein profiles of patients.Materials and MethodsThe present cross-sectional study consisted of 50 women with PCOS, who referred to theKermanshah University of Medical Sciences Clinic between April and October 2015, and 233 unrelated age-matchedhealthy women from the same region (West Iran). The PPARγ Pro12Ala and PPARγ C161T polymorphisms were gen-otyped using the polymerase chain reaction-restriction fragment length polymorphism method. Fasting blood sugar(FBS), serum triglycerides (TG), cholesterol, low density lipoprotein- cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C) and estradiol levels were measured.ResultsThe serum level of estradiol was significantly lower in PCOS patients compared to healthy women. The PPARγPro12Ala (CG) genotype increased the risk of PCOS 2.96-fold. The frequency of the PPARγ T allele (at C161T) was 21%in patients and 17.2% in controls with no significant difference (P=0.52). In all studied individuals, the PPARγ CG geno-type was associated with significantly higher levels of TG. However, significantly lower levels of total cholesterol andLDL-C were observed in PPARγ TT individuals compared with those with the CC genotype. Within the PCOS group, thePPARγ CG genotype was significantly associated with lower levels of estradiol compared with the CC genotype. Also,the CG genotype was significantly associated with higher levels of TG when compared with the CC genotype.ConclusionOur study shows that, unlike PPARγ C161T, PPARγ Pro12Ala is associated with the risk of PCOS. Also,we found that the lipid and lipoprotein profiles significantly vary based on PPARγ Pro12Ala and C161T genotypes.

【 授权许可】

Unknown