High Temperature—Short Time Pasteurization Has a Lower Impact on the Antiviral Properties of Human Milk Than Holder Pasteurization

Frontiers in Pediatrics

Laura Cavallarin¹  Marzia Giribaldi²  Guido E. Moro³  Rachele Francese⁴  David Lembo⁴  Massimo Rittà⁴  Andrea Civra⁴  Manuela Donalisio⁴  Alessandra Coscia⁵  Paola Tonetto⁵  Enrico Bertino⁵ 

[1] Consiglio Nazionale delle Ricerche-Istituto di Scienze delle Produzioni Alimentari, Bari, Italy;Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria, Centro di Ricerca in Ingegneria e Trasformazioni Agroalimentari, Turin, Italy;Italian Association of Human Milk Banks, Milan, Italy;Laboratory of Molecular Virology, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy;Neonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy;

关键词: human milk;    HTST;    Holder;    antiviral activity;    virus;    pasteurization;   

DOI  :  10.3389/fped.2018.00304

来源: DOAJ

【 摘 要 】

Holder pasteurization (62. 5°C for 30 min) is recommended by all international human milk bank guidelines to prevent infections potentially transmitted by donor human milk. A drawback is that it affects some human milk bioactive and nutritive components. Recently, High Temperature-Short Time (HTST) pasteurization has been reported to be a valuable alternative technology to increase the retention of some biological features of human milk. Nevertheless, to date, few data are available about the impact of pasteurization methods other than Holder on the antiviral activity of human milk. The present study was aimed at evaluating the antiviral activity of human milk against a panel of viral pathogens common in newborns and children (i.e., herpes simplex virus 1 and 2, cytomegalovirus, respiratory syncytial virus, rotavirus, and rhinovirus), and at assessing the effect of Holder and HTST pasteurization on milk's antiviral properties. The results indicate that human milk is endowed with antiviral activity against all viruses tested, although to a different extent. Unlike the Holder pasteurization, HTST preserved the inhibitory activity against cytomegalovirus, respiratory syncytial virus, rotavirus and herpes simplex virus type 2. By contrast, both methods reduced significantly the antiviral activities against rhinovirus and herpes simplex virus type 1. Unexpectedly, Holder pasteurization improved milk's anti-rotavirus activity. In conclusion, this study contributes to the definition of the pasteurization method that allows the best compromise between microbiological safety and biological quality of the donor human milk: HTST pasteurization preserved milk antiviral activity better than Holder.

【 授权许可】

Unknown