Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients

Life

Edison Jahaj¹  Maria. G. Detsika¹  Ioanna Dimopoulou¹  Stylianos E. Orfanos¹  Anastasia Kotanidou¹  Chara Giatra²  Maria Pagoni²  Diamanto Kouniaki³  Vasiliki Kitsiou³  Alexandra Tsirogianni³  Theofilos Athanassiades³  Katerina Tarassi³ 

[1] Department of Critical Care Medicine & Pulmonary Services, School of Medicine, G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece;Hematology Department, BMT Unit, “Evangelismos” Hospital, 10676 Athens, Greece;Immunology-Histocompatibility Department, “Evangelismos” Hospital, 10676 Athens, Greece;

关键词: SARS-CoV-2;    coronavirus disease 2019 (COVID-19);    immunology;    human leucocyte antigens;    immunogenetics;   

DOI  :  10.3390/life11101017

来源: DOAJ

【 摘 要 】

The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mild n = 69) and hospitalized (n = 56). Analysis of disease characteristics revealed no major differences between males and females of each group of patients while hospitalized patients were older and presented with comorbidities. A positive allele association was observed for HLA-DRB1*01 in total COVID-19 patients versus healthy controls. Subgrouping of COVID-19 patients in mild and hospitalized further identified a statistically significant increase in HLA-DRB1*01 in mild COVID-19 patients versus controls. The frequency of A*11, A*23, and DRB1*09 alleles was higher, while the frequency of C*12 was lower, in hospitalized patients versus healthy controls albeit with uncorrected statistical significance. The identification of specific allele associations may provide useful future markers for disease susceptibility in order to allow successful clinical management of COVID-19 patients.

【 授权许可】

Unknown