Adolescent with severe granulomatosis with polyangiitis: case report

The Pan African Medical Journal

Hamza Elkihal¹  Hasna Jabri¹  Wiam Elkhattabi¹  Hicham Afif¹  Hajar Arfaoui¹ 

[1] Department of Respiratory Diseases, Hospital 20 Août 1953, University of Hassan II, University Hospital Center Ibn Rochd, Casablanca, Morocco;

关键词: granulomatosis with polyangiitis;    wegener’s granulomatosis;    pediatric gpa;    anca-associated vasculitis;    case report;   

DOI  :  10.11604/pamj.2021.38.285.26893

来源: DOAJ

【 摘 要 】

Granulomatosis with polyangiitis (GPA) is a rare vasculitis among adolescents. Its pulmonary manifestations may mimic tuberculosis. We report the case of a 16 year old female patient with multiple excavated lung nodules revealed by a chronic cough, hemoptysis, epistaxis and weight loss. The diagnosis of GPA was achieved due to systemic pulmonary, ENT and renal involvement, the positivity of anti-neutrophil cytoplasmic antibody directed against proteinase 3 (C-ANCA) and bronchial and nasal biopsies showing granulomatous inflammation with a dense perivascular infiltrate destroying the vessel wall. Bolus of glucocorticoids and immunosuppressants reversed her symptoms. Although GPA is a rare disease in teenagers, it should be considered as one of the differential diagnosis in adolescents presenting with excavated pulmonary nodules.

【 授权许可】

Unknown