PHOTOACOUSTIC VISCOELASTICITY IMAGING OF BIOLOGICAL TISSUES WITH INTENSITY-MODULATED CONTINUOUS-WAVE LASER

Journal of Innovative Optical Health Sciences

SIHUA YANG¹  YUE ZHAO¹ 

[1] MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, P. R. China;

关键词: Photoacoustic;    phase delay;    viscoelasticity;    imaging;   

DOI  :  10.1142/S1793545813500338

来源: DOAJ

【 摘 要 】

In this paper, a novel photoacoustic viscoelasticity imaging (PAVEI) technique that provides viscoelastic information of biological tissues is presented. We deduced the process of photoacoustic (PA) effect on the basis of thermal viscoelasticity theory and established the relationship between the PA phase delay and the viscoelasticity for soft solids. By detecting the phase delay of PA signal, the viscoelasticity distribution of absorbers can be mapped. Gelatin phantoms with different densities and different absorption coefficients were used to verify the dependence of PAVEI measurements. Moreover, tissue mimicking phantoms mixed with fat and collagen at different concentrations were used to testify the feasibility of this technique with reliable contrast. Finally, the PAVEI was successfully applied to discrimination between biological tissue constituents. Our experimental results demonstrate that this novel technique has the potential for visualizing the anatomical and biomechanical properties of biological tissues.

【 授权许可】

Unknown