TGF‐β‐secreting regulatory B cells: unsung players in immune regulation

Clinical & Translational Immunology

Charles Gerard Rickert¹  James F Markmann¹  Shaoping Deng²  Guoli Huai² 

[1] Center for Transplantation Sciences Massachusetts General Hospital Harvard Medical School Boston MA USA;Organ Transplantation Center Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China;

关键词: allergy;    autoimmune diseases;    cancer;    TGF‐β+ regulatory B cells;    transplantation;   

DOI  :  10.1002/cti2.1270

来源: DOAJ

【 摘 要 】

Abstract Regulatory B cells contribute to the regulation of immune responses in cancer, autoimmune disorders, allergic conditions and inflammatory diseases. Although most studies focus on regulatory B lymphocytes expressing interleukin‐10, there is growing evidence that B cells producing transforming growth factor β (TGF‐β) can also regulate T‐cell immunity in inflammatory diseases and promote the emergence of regulatory T cells that contribute to the induction and maintenance of natural and induced immune tolerance. Most research on TGF‐β+ regulatory B cells has been conducted in models of allergy, cancer and autoimmune diseases, but there has, as yet, been limited scrutiny of their role in the transplant setting. Herein, we review recent investigations seeking to understand how TGF‐β‐producing B cells direct the immune response in various inflammatory diseases and whether these regulatory cells may have a role in fostering tolerance in transplantation.

【 授权许可】

Unknown